| 摘 要: 细胞自噬是一种“清道夫”式的细胞保护程序，保护自身细胞不受来自内部或外界的伤害。随着细胞自噬研究的深入进展，科学家们开始关注于与细胞自噬相关的其他方面问题的研究，其中纳米材料诱导的细胞自噬得到了高度关注。且越来越多的研究表明，纳米材料能引起细胞自噬。本文就当前关于纳米材料与细胞自噬的关系的现有研究结果出发，针对水溶性富勒烯及其衍生物、稀土金属氧化物、量子点、石墨烯等纳米材料对细胞自噬的诱导和抑制作用，做简单综述。 |
| 关键词: 纳米材料 自噬 分子机制 |
|
中图分类号: R99
文献标识码:
|
| 基金项目: 国家自然科学基金（编号：81602893）；山东省自然科学基金（编号：ZR2015YL049）；山东省医药卫生科技发展计划（编号：2016WS0581470145）；山东省医学科学院创新工程 |
|
| Progress in study on cell autophagy induced by nanomaterials |
|
Yang Ye，Chen Shangya，Zhang Enguo，Jia Qiang，Du Zhongjun,，Shao Hua
|
|
School of Medicine and Life Sciences，University of Jinan，Shandong Academy of Medical Sciences，Jinan 250062，China
|
| Abstract: Autophagy was a scavenger type of self-protection program which could protect their own cells from internal or external damage. With the progress of autophagy research，scientists began to focus on other aspects related to autophagy，especially that caused by nanomaterials. More and more studies has shown that nanomaterials could cause cell autophagy. This paper briefly introduced the effects of such nanomaterials as water-soluble fullerenes and their derivatives，rare earth metal oxides，quantum dots and graphene on cell autophagy induction and inhibition based on the current research results of the relationship between nanomaterials and autophagy. |
| Keywords: nanomaterials autophagy molecular mechanism |
