| 摘 要: 职业性尘肺病是我国发病率和死亡率最高的职业病， 尘肺病是以进行性肺间质纤维化为特征的肺部疾病，
但临床缺乏特效药物及早期筛选的分子标志物， 利用生物样本库及蛋白组学技术， 筛选和研究尘肺病患者血液、支气
管肺泡灌洗液等特异性蛋白的差异表达， 将有利于特效药物的研发及早期分子标志物的建立 |
| 关键词: 生物样本库 尘肺 蛋白组学 |
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| Prospects on application of pneumoconiosis proteomics biobank |
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He Jin, Liu Guangfeng, Cui Ping
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Shandong Academy of Occupational Health and Occupational Medicine, Jinan 250062, China
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| Abstract: The pneumoconiosis had the highest morbidity and mortality among occupational diseases in China. Pneumoconiosis was occupational lung disease characterized by progressive pulmonary fibrosis, but clinical treaments lacked of efficacious drug and molecular marker in early diagnosis. Differential protein expression of blood samples and bronchoalveolar lavage fluid were analyzed by tissue of biobanks and proteomics technology. This would made for development of efficacious drug and establishment of molecular marker in early diagnosis. |
| Keywords: biobank pneumoconiosis proteomics |
