摘 要: 矽肺病是一种长期暴露于二氧化硅粉尘导致的慢性肺间质性肺疾病,其主要特征为肺部炎症和进行性肺纤维化。随着肺纤维化的发展,矽肺病情会进一步加重,严重影响着人们的身体健康与生活质量。目前虽无有效的治疗药物,但随着国内外科研人员对矽肺肺纤维化发病机制和病理生理变化的深入研究,针对矽肺肺纤维化治疗药物的研究也取得了一定进展。本文拟主要从天然药物、合成药物和生物药物三个方面对近几年研究的抗矽肺肺纤维化的药物进行简要概述。 |
关键词: 矽肺 肺纤维化 治疗药物 |
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Research progress on therapeutic drugs for silicotic pulmonary fibrosis |
GUO Jing-wen, ZHANG Zhen-ling, SHAO Hua
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School of Medicine and Life Sciences, University of Jinan,Jinan 250062, China
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Abstract: Silicosis is a chronic interstitial lung disease caused by long term exposure to silica dusts in occupational environment. Its main features are lung inflammation and progressive pulmonary fibrosis, and with the development of the fibrosis, the disease was further aggravated as well, which will seriously affect the health and life quality of the patient. There is still no efficient therapeutic drug yet, but with domestic and abroad research progress on pathogenesis and pathophysiology of pulmonary fibrosis in silicosis, the study on the drug for silicotic pulmonary fibreosis has also made some progress. This article will briefly summarize recent progress of the studies on three main kinds of anti-silicotic pulmonary fibrosis drugs, namely natural medicine, synthetic drugs and biological drugs. |
Keywords: silicosis pulmonary fibrosis therapeutic drugs |