| 摘 要: 纳米二氧化硅以其独特的理化性质广泛应用于航空、航天、军事、食品、医学等诸多领域，与人类的接触机会日益增加。纳米二氧化硅对人体毒性及机制研究已成为当下研究热点。本文综合国内外最新研究成果，从人类纳米二氧化硅暴露环境、进入途径，对呼吸、心血管、生殖、神经、肾脏等多系统毒性，以及氧化应激、炎症反应、DNA损伤、细胞器的功能障碍、自噬、凋亡、表观遗传学改变机制等方面进行阐述。 |
| 关键词: 纳米二氧化硅 系统毒性 毒性机制 |
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中图分类号: R135.2
文献标识码: A
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| 基金项目: 国家自然基金（No.81773373） |
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| Systematic toxicities and toxic mechanisms of silica nanoparticles |
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XU Ya-hui，ZHANG Hua，Hu Qing-fang，XIU Lin-qing，ZHANG Chun-ling
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The Second Clinical College of Qingdao University，Qingdao 266042，China
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| Abstract: Silica nanoparticles have been widely used in many fields, such as aviation, aerospace, military, food and medicine, etc., because of its unique physical and chemical properties, therefore, its toxicity and mechanism to human body have become a research hotspot nowadays. This paper synthesizes the latest research results at home and abroad in this field, including exposed environments to silica nanoparticles, ways of invasion into human body, toxicities to systems or organs such as respiratory, cardiovascular, reproductive, nervous, and kidney, etc., and the mechanisms such as oxidative stress, inflammatory reaction, DNA damage, organelle dysfunction, autophagy, apoptosis, epigenetic changes, etc. |
| Keywords: silica nanoparticles system toxicity toxicity mechanism |
