摘 要: 碑作为一种同时具有“致癌”和“治癌”双面生物学效应的类金属元素,是一种严重危害人类健康的环境剧毒污染物和确定的人类致癌物。长链非编码RNA(LncRNA)水平异常是当前碑毒性研究的前沿和热点。大量研究显示,LncRNA水平紊乱参与碑暴露所致肝癌、肺癌、血液恶性肿瘤、乳腺癌等的发生发展,还与碑损伤心血管系统、生殖系统以及皮肤等密切相关。本文基于最新研究进展,对LncRNA在碑的毒性损伤机制中的作用进行总结归纳,以期为碑毒性的防治研究提供参考。 |
关键词: 碑暴露 长链非编码RNA(Lnc.RNA) 毒性损伤 亚碑酸盐 三氧化二碑(As2O3) |
中图分类号: R994.3
文献标识码: A
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基金项目: 大理大学2018年博士科研启动基金项目(KYBS2018006) |
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Research progress of long non-coding RNA involved in arsenic toxicity |
ZHANG Xiao-li,GU Shi-yan,QU Teng-jiao,MOU Ya-hao,WANG Yi-xuan,ZHENG Jing,HE Zuo-shun
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School of Public Health,Dali University,Dali 671000,China
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Abstract: Arsenic,as a metal-like element with both“carcinogenic"and"anti-cancer"biological effects,is a highly toxic environmental pollutant and a confirmed human carcinogen that seriously endangering human health.The abnormal level of long non-coding RNA(LncRNA)is the frontier and hotspot of arsenic toxicity research.A large number of studies have shown that the disorder of LncRNA involved in the occurrence and development of liver cancer,lung cancer,hematological malignancies,breast cancer,etc.,and closely related to the damages of arsenic to cardiovascular,reproductive and skin systems.In this paper,based on the latest research progress,the mechanism of LncRNA in toxic injury by arsenic exposure was summarized,so as to provide reference for the prevention and treatment of arsenic toxicity. |
Keywords: arsenic exposure long non-coding RNA(LncRNA) toxic injury arsenite arsenic trioxide(As2O3) |