摘 要: 镉是自然界天然存在的重金属元素。我国部分地区土壤存在不同程度的镉污染,农作物和饮水中也存在不同程度的镉残留。镉可引起多器官损伤,尤其以对肝脏、肾脏和骨骼损害最为明显。镉引起的“痛痛病”与机体本身的营养状态有关,尤其是维生素D缺乏。维生素D是一种脂溶性维生素,其代谢异常及继发的钙磷代谢障碍可导致骨质疏松、骨软化等疾病的发生。肾脏、肝脏和骨骼是维生素D的代谢及作用的主要场所。本文拟就镉对维生素D代谢途径的干扰作用及缺乏或补充维生素D对镉毒性效应的影响进行简要综述,以期为探究维生素D作为预防或缓解镉引起的肝脏、肾脏、骨骼和肠道毒性的可行性提供一些理论基础。 |
关键词: 镉 维生素D 肝肾毒性 骨骼毒性 |
中图分类号: R994.3
文献标识码: A
|
基金项目: 上海市科学技术委员会国内合作项目(20015800300);上海市青年科技英才扬帆计划资助(20YF1441200) |
|
Research progress on effect of vitamin D in cadmium toxicity |
LI Yan-ping,MIN Zhen,SUN Dao-yuan,CHOU Xin
|
The Third People's Hospital of Honghe Prefecture,Gejiu 661000,China
|
Abstract: Cadmium is a naturally produced heavy metal element,human activities and natural movement can also produce cadmium,resulting in cadmium pollution.In some areas of China,there were different degrees of cadmium pollution in soil,as well as some cadmium residue in crops and drinking water were found.Cadmium can cause multiple organs damage,especially liver,kidney and bone.Some scholars believe that the‘Itai-itai disease'caused by cadmium is also related to the nutritional status,especially vitamin D deficiency.Vitamin D is a fat-soluble vitamin,abnormal vitamin D metabolism and secondary calcium and phosphorus metabolic disorders can cause osteoporosis and osteomalacia,etc.Kidney,liver and bone are also the main sites of metabolism and action of vitamin D.This article would make a brief review on the interference role of cadmium in vitamin D metabolic pathways and the effect of Vitamin D deficiency or supplement on the toxic effects of cadmium,thereby,providing some theoretic basis for exploring the feasibility of vitamin D to prevent or alleviate liver,kidney,bone,and intestinal toxicity caused by cadmium. |
Keywords: cadmium vitamin D hepatic and renal toxicity bone toxicity |