摘 要: 目的 探讨急性百草枯中毒患者血清肌腱蛋白C(TNC)、胰石蛋白(PSP)、动脉血乳酸(Lac)水平与中毒严重指数(PSI)关系及预后预测效能。方法 选取2019年8月—2020年8月我院收治的60例急性百草枯中毒患者作为研究对象,对比不同中毒程度、不同预后患者TNC、PSP、Lac水平及PSI,从而评价TNC、PSP、Lac水平联合检测对急性百草枯中毒患者预后影响。结果 急性百草枯中毒患者不同中毒程度TNC、PSP、Lac水平及PSI组间比较差异有统计学意义(P<0.05);TNC、PSP、Lac水平均与PSI呈正相关(P<0.05);急性百草枯中毒死亡患者TNC、PSP、Lac水平及PSI均高于生存患者(P<0.05);TNC、PSP、Lac联合检测对急性百草枯中毒患者预后的预测效能高于单一指标检测(P<0.05)。结论 急性百草枯中毒患者血清TNC、PSP和动脉Lac水平出现明显异常变化,且与PSI及预后密切相关,可作为预后评价的标志物。 |
关键词: 急性百草枯中毒 肌腱蛋白C(TNC) 胰石蛋白(PSP) 动脉血乳酸(Lac) 中毒严重指数(PSI) 预后 |
中图分类号: R595.4
文献标识码: A
|
基金项目: 河北省卫生健康委医学科研课题计划项目(编号:20200404) |
|
Relationship between serum tenascin C,pancreatic stone protein,arterial blood lactic acid level and poisoning severity index in patients with acute paraquat poisoning |
YANG Yu-dan,YU Yu-lan,WANG Wei-zhan
|
Hengshui Municipal People's Hospital,Hengshui 053000,China
|
Abstract: Objective To investigate the relationship between serum tenascin C(TNC),serum pancreatic stone protein(PSP),arterial blood lactic acid(Lac)level and poisoning severity index(PSI)in patients with acute paraquat poisoning. Methods 60 patients with acute paraquat poisoning treated in our hospital during August 2019 to August 2020 were selected as research objects,then the differences among serum levels of TNC and PSP,the arterial blood Lac level and PSI according to the data of the patients with different severities of poisoning and different prognosis were compared,thereby the relationship between TNC,PSP,Lac levels and PSI and its role played in prognosis judgment were well assessed. Results The results showed that there were statistically significant differences in TNC,PSP,Lac and PSI among the patients with different severities of acute paraquat poisoning(P<0.05),the levels of TNC,PSP,Lac were all positively correlated with PSI of patients(P<0.05),and the indices mentioned above in died cases of acute paraquat poisoning were all higher than those of surviving patients(P<0.05),TNC,PSP,Lac levels and PSI were all prognostic factors in patients with acute paraquat poisoning,additionally,the predictive effect of combined detection of TNC,PSP,and Lac was higher than that of any single detection in patients with acute paraquat poisoning(P<0.05). Conclusion The results suggested that the levels of TNC,PSP,and Lac in patients with acute paraquat poisoning were obviously abnormal and closely related to PSI and prognosis the disease,therefore,these changes might be used as the markers for prognosis judgment. |
Keywords: acute paraquat poisoning tenascin C(TNC) pancreatic stone protein(PSP) arterial blood lactic acid(Lac) poisoning severity index(PSI) prognosis |