摘 要: 目的 探讨血清N端脑钠肽前体(NT-proBNP)水平的动态变化对化学烧伤脓毒症患者病情评估及预后的预警价值。方法 选取42例职业性化学烧伤脓毒症患者,根据患者21 d后生存情况分为生存组(26例)、死亡组(16例)。检测患者伤后第3、7、14、21天的血清NT-proBNP水平,观察两组患者血清NT-proBNP变化特点。结果 死亡组伤后第14天和第21天血清NT-proBNP值均显著高于生存组(P<0.01);ROC曲线分析显示,△NT-proBNP3~14 (伤后第3天与第14天NT-proBNP的差值)的曲线下面积(AUC)为0.916,当△NT-proBNP3~14>4 715 pg/ml时,预测患者预后不良(死亡)的敏感度为87.5%、特异度为88.46%。结论 血清NT-proBNP水平的动态监测对评估化学烧伤脓毒症患者病情危重程度、预测预后有很好的预警价值。 |
关键词: 化学烧伤 脓毒症 N端脑钠肽前体(NT-proBNP) 预后 |
中图分类号: R446.1
文献标识码: A
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基金项目: |
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Early warning value of NT-proBNP in patients with chemical burn sepsis |
CHU Dan
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The Fourth Affiliated Hospital of Nankai University,Tianjin 300222,China
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Abstract: Objective To investigate the value of changes of serum N-terminal pro-brain natriuretic peptide (NT-proBNP)in severity assessment and prognostic judgement for patients with chemical burn sepsis. Methods A total of 42 patients with occupational chemical burn sepsis were selected as research objects,and divided into survival group(26 patients)and death group(16 patients)according to the clinical outcome at the 21th day after poisoning. The serum NT-proBNP values of patients were detected on the 3rd,7th,14th and 21st day after burning,then compare the changes of serum NT-proBNP levels of the patients of two groups. Results The results showed that the serum NT-proBNP levels of death group were significantly higher than that of the survival group on the 14th and 21st day after burning(P<0.01);ROC curve analysis showed that the area of △NT-proBNP3~14(means the difference of NT-proBNP between the 3rd and 14th day after burning)curve was 0.916;when the value of △NT-proBNP3~14>4 715 pg/ml,the sensitivity of predicting poor prognosis(death)for patients was 87.5% and its specificity was 88.46%. Conclusion The results suggested that the dynamic monitoring of serum NT-proBNP level had a good early warning value for assessing the severity of patients with chemical burn sepsis and predicting the prognosis. |
Keywords: chemical burn sepsis N-terminal pro-brain natriuretic peptide(NT-proBNP) prognosis |