| 摘 要: 矽肺是以肺部弥漫性纤维化为特征的一种尘肺病。目前矽尘致肺纤维化的确切机制尚不清楚，缺乏反映肺纤维化程度的特征指标，也无突破性的治疗药物及针对性的治疗措施。干细胞治疗主要是通过调节炎症、减少纤维化和细胞凋亡而达到改善肺功能的目的。由于需要持续注射较大剂量的干细胞，且存在长期的慢性炎症反应，可能会影响干细胞的比例，目前尚不宜广泛应用于临床治疗，其安全性、可靠性还需大量实验研究加以证实。本文综述了近年矽肺发病机制及干细胞治疗的研究进展。 |
| 关键词: 二氧化硅（SiO2） 矽肺 干细胞治疗 |
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中图分类号: R135.2
文献标识码: A
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| 基金项目: |
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| Research progress in pathogenesis and stem cell therapy of silicosis |
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ZOU You-shuo，ZHAO Yang
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Shenyang Ninth People's Hospital，Shenyang 110024，China
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| Abstract: Silicosis is a pneumoconiosis characterized by diffuse pulmonary fibrosis. As the exact mechanism of pulmonary fibrosis caused by silica dust is still unclear，and a lack of characteristic indicators reflecting the degree of pulmonary fibrosis，there is no targeted therapeutic drug or measure yet as well. The main aim of stem cell therapy is mainly to improve lung function by regulating inflammation，reducing fibrosis and cell apoptosis. However，because of that the cell therapy requires continuous injec tion of larger doses of stem cells，and that the long-term chronic inflammatory response existed will affect the proportion of stem cells，therefore，it still cannot be widely used in clinical treatment，its safety and reliability need further studied through a large number of experiments，too. This article reviews the progress in main pathogenesis of silicosis and stem cell treatment on silicosis. |
| Keywords: SiO2 particles silicosis stem cells therapy |
