摘 要: 噪声暴露、耳毒性药物、衰老等因素均可造成听觉系统损伤,导致听力下降。听觉系统损伤造成听力异常的主要表现为听力阈值升高、语言接受和信号辨别能力下降;主要病理改变为螺旋器纤毛破坏、毛细胞丢失以及支持细胞的损伤。研究表明,造成听觉系统损伤的主要原因是氧化应激反应产生大量的活性氧(ROS),破坏了体内的稳态环境;而ROS对听觉细胞的损伤大部分依赖于激活腺苷酸活化蛋白激酶(AMPK)来实现。为此,本文拟对听觉系统损伤及其AMPK相关机制作一综述。 |
关键词: 听力损伤 活性氧(ROS) 氧化应激 腺苷酸活化蛋白激酶(AMPK)途径 |
中图分类号: TB53
文献标识码: A
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基金项目: 国家自然科学基金面上项目(81673136) |
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Study on auditory system injury and related mechanism of AMPK |
ZHANG An-ran,HOU Jian-wu,GAO Yun-long,CUI Bo,WANG Rui
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Shandong First Medical University/Shandong Provincial Academy of Occupational Health and Occupational Medicine/Shandong Provincial Institute of Occupational Health and Occupational Control,Jinan 250062,China
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Abstract: Noise exposure,ototoxic drugs,aging and other factors all can induce damage to auditory system,leading to hearing loss. The main performance of abnormal hearing by auditory system damage are the increase of hearing threshold and the decline of language acceptance and the drop of signal discrimination ability;the main pathological changes are the destruction of spiral cilia,the loss of hair cells and the damage of supporting cells. Study shows that the main reason for auditory system damage is the reactive oxygen species(ROS)caused by oxidative stress reaction,which destroies the homeostasis of the body,while the damage by ROS to auditory cells mostly depends on the activation of adenosine that further activates protein kinase(AMPK). Therefore,this article will focus on the auditory system damage and its AMPK related mechanism. |
Keywords: hearing loss reactive oxygen species(ROS) oxidative stress adenosine 5'-monophosphate(AMP) -activated protein kinase(AMPK)pathway |