摘 要: 3-硝基-1,2,4-三唑-5-酮(NTO)是一种不敏感含能材料,因其爆轰速度和压力与六氢-1,3,5-三硝基-1,3,5-三嗪(RDX)相似,合成和运输安全,已逐渐成为传统含能材料的替代品。近年来,随着国内外对含能材料毒性研究的不断深入,已证实NTO对生物体及生态系统具有多种毒性效应,主要表现为对哺乳动物的睾丸毒性。本文从生物代谢、生物毒性及生态毒性三个方面对NTO毒性进行系统概述,展望今后NTO毒性的研究方向,以期为NTO的职业健康风险评估提供可靠的毒理学基础。 |
关键词: 3-硝基-1,2,4-三唑-5-酮(NTO) 含能材料 毒性 睾丸毒性 |
中图分类号: R994.3
文献标识码: A
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基金项目: |
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Toxicological characteristics of 3-nitro-l,2,4-triazol-5-one |
LI Huan,LIU Zhi-yong,LU Zhi-yan,GAO Ting,DENG Hui,GAO Jun-hong
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Ordnance Industrial Hygiene Research Institute,Xi'an,Shanxi 710065,China
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Abstract: Nitrotriazolone(3-nitro-1,2,4-triazol-5-one,NTO),is an insensitive energetic material,owing to detonation velocity and pressure are similar to RDX,while more safe in synthesis and transportion,it has gradually become a substitute for traditional energetic materials. In recent years,with the deepening of the research on the toxicity of energetic materials at home and abroad,it has been proven that NTO has a variety of toxic effects on organisms and ecosystems,mainly infested as testicular toxicity to mammals. This article will provide a systematic overview of NTO toxicity from these three aspects:biological metabolism,biological toxicity,and ecological toxicity,then prospects the research direction of NTO toxicity in future,thereby provide a reliable toxicological basis for the occupational health risk assessment. |
Keywords: nitrotriazolone(3-nitro-1,2,4-triazol-5-one,NTO) energetic material toxicity testicular toxicity |