摘 要: 沉默信息调节因子1(Sirtuin1,silent information regulator 1,SIRT1)是与酿酒酵母沉默信息调节器2(Sir2)同源的去乙酰化酶家族。SIRT1通过介导多条细胞信号通路,在细胞生物学功能和疾病发生机制中发挥关键作用,调节各种疾病的病理进展。在急性肺损伤(acute lung injury,ALI)/急性呼吸窘迫综合征(acute respiratory distress syndrome,ARDS)的动物模型中,SIRT1表达异常,且表达水平与模型的疾病严重程度密切相关,可能成为早期诊治ALI/ARDS新的生物学指标。本文简要综述了SIRT1通过抗炎、抗氧化应激、调节细胞凋亡及自噬、改变血管内皮细胞通透性等途径发挥其减轻ALI/ARDS的作用,探讨SIRT1在ALI/ARDS防治中的潜在价值。 |
关键词: 沉默信息调节因子1(SIRT1) 生物学功能 急性肺损伤/急性呼吸窘迫综合征(ALI/ARDS) |
中图分类号: R563
文献标识码: A
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基金项目: 内蒙古自治区自然科学基金(2023MS08019,2018LH08002);内蒙古自治区健康科技计划项目(202201011);内蒙古自治区人民医院院内基金(2020YN06);内蒙古医科大学联合项目(YKD2022LH015) |
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Sirtuin1 and acute lung injury/acute respiratory distress syndrome |
YUE Yang,XU Tianxiang,DAI Qin,LÜ Hongxu,WANG Xiaoxia
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Inner Mongolia Clinical Medical College,Inner Mongolia Medical University,Hohhot, Inner Mongolia 010110,China
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Abstract: Sirtuin1 (silent information regulator 1, SIRT1) is a family of deacetylases homologous to silent information regulator 2 (Sir2) in Saccharomyces cerevisiae.SIRT1 plays a crucial role in cellular biological function and disease pathogenesis by mediating multiple cellular signaling pathways,regulating pathological progression of various diseases.In animal models of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS),SIRT1 show abnormal expression and the expression level is closely related to the severity of the disease in the model,therefore, it is expected to become a new emerging biological indicator for early diagnosis and treatment of ALI/ARDS.This article briefly reviews the role of SIRT1 in reducing ALI/ARDS through anti-inflammatory, antioxidant stress,regulating cell apoptosis and autophage, and altering endothelial cell permeability,and the potential value of SIRT1 in the prevention and treatment of ALI/ARDS is explored as well. |
Keywords: Sirtuin1 (silent information regulator 1,SIRT1) biological function acute lung injury (ALI)/acute respirtatory distress syndrome (ARDS) |