摘 要: 环境内分泌干扰物(EEDs)污染是一种新型地球环境污染问题,近年来许多学者发现EEDs可能对雄性的生殖健康产生严重危害。前列腺素E2(PGE2)由下丘脑星形胶质细胞产生并释放到相邻的促性腺激素释放激素(GnRH)神经元间接调控生殖。本文拟就在EEDs对雄性健康的影响及PGE2在其中的作用加以综述。 |
关键词: 环境内分泌干扰物(EEDs) 雄性生殖 前列腺素E2(PGE2) 促性腺激素释放激素(GnRH) |
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基金项目: 国家自然科学基金项目(编号81302406) |
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Role of PGE2 in effect of environmental endocrine disruptors on male reproductive health |
WU Feng-di, DENG Yu
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Abstract: Environmental endocrine disruptors (EEDs) contamination is a new type of global environmental pollution problem,scholars have found that EEDs can cause serious damage to male reproductive health. Prostaglandin E2 (PGE2) is produced by hypothalamic astrocytes and released to adjacent GnRH neurons, which may indirectly regulate reproduction. This paper will give a brief review on the effect of EEDs to male health and the role of PGE2 in the effect of EEDs on male health. |
Keywords: Environmental endocrine disruptors (EEDs) male reproductive prostaglandin E2 (PGE2) gonadotropin-releasing hormone (GnRH) |