摘 要: 目的探讨煤矿接矽尘工人血清中总抗氧化能力(total antioxidant capacity,TAC)、转化生长因子-β1(transfonning growth factor-β1,TGF-β1)表达水平与矽肺的相关性。方法采用限制性三次样条(restricted cubic spline,RCS)结合Logistics回归,分析随机选取的137例煤矿工人(接尘组)和94例壹期矽肺患者(病例组)血清中TAC与TGF-β1的剂量-效应关系及其对矽肺发病的影响。结果TAC、TGF-β1、年龄及吸烟在接尘组和病例组之间差异有统计学意义(P<0.05);接尘组血清TAC水平工龄11〜20年组高于1〜10年组,差异有统计学意义(P<0.05);病例组血清TGF-β1水平工龄11〜20年组低于1〜10年、21〜38年组,差异均有统计学意义(P<0.05)。RCS模型分析结果显示,接尘组和病例组TAC、TGF-β1水平间均存在相关性,且在接尘组中两者呈非线性关系(总体关联性检验χ2=8.010,P=0.046和χ2=7.870,P=0.049;非线性检验χ2=6.580,P=0.037和χ2=3.340,P=0.188)。多因素分析显示,调整潜在混杂因素后(年龄、文化程度、接尘工龄、开始接尘年龄和吸烟),TGF-β1与矽肺发病风险升高有关(OR=1.022,95%CI 1.006〜1.039),TAC与矽肺发病风险降低有关(OR=0.897,95%CI 0.847〜0.951)。结论煤矿接尘工人及矽肺患者血清TAC、TGF-β1含量与矽肺相关。 |
关键词: 矽肺 掘进工 总抗氧化能力(TAC) 转化生长因子书1(TGF-pl) |
中图分类号: R135.2
文献标识码: A
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基金项目: 国家自然科学基金项目(81773399);中国煤炭工业协会2018年指导性计划项目(MTKJ-2018284);华北理工大学研究生创新项目(2017B12) |
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Correlation between serum TAC,TGF-β1 and silicosis in coal mine workers exposed to silica dust |
ZHAO Ying-zheng,CHANG Mei-yu,XIONG Cheng,GUAN Yi,SI Xue-zhe,LI Zhi-heng,LI Guo-feng,LI Hai-bin,LI Yu-chun,XU Guang-cui,Wang Yong-bin,YAO San-qiao
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College of Public Health,North China University of Science and Technology,Tangshan 063000,China
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Abstract: Objective To investigate the correlation between serum total antioxidant capacity(TAC),transforming growth factor-β1(TGF-β1)and silicosis in coal mine workers exposed to silica dust. Methods A total of 137 coal mine workers and 94 patients with stage I silicosis were randomly selected as the study subjects,and the restricted cubic spline(RCS)and Logistic regression methods were used for the analysis of the dose-response relationship between silicosis and serum TAC or TGF-β1.Results The results showed that there were statistically significant differences in TAC and TGF-β1 content in serum,age,and smoking between dust exposed group and silicosis group(P<0.05);the serum TAC levels in 11〜20 years subgroup was higher than that in 1〜10 years subgroup in dust exposed group,the difference was statistically significant(P<0.05),while the serum TGF-β1 content in 11〜20 years subgroup was lower than that in 1〜10 years subgroup and 21〜38 years subgroup in silicosis group, the difference was statistically significant(P<0.05).furthennore,the results of RCS showed that there was some coiTelation between TAC and TGF-β1 content both in dust exposure group and silicosis group,but the correlation in dust exposure group was non-linear(the overall correlation test:X2=8.010,P=0.046 and X2=7.870,P=0.049;the non-linear test:X2=6.580,P=0.037 and X2=3.340,P=0.188). The multivariate analysis showed that serum level of TGF-β1 was associated with the increased risk of silicosis(OR=1.022,95%CI 1.006〜1.039)and TAC was associated with the decreased risk of silicosis(OR=0.897,95%CI 0.847〜0.951)after adjusting for potential confounding factors including age,education level,duration of dust exposure,age of dust exposure,smoking,etc.Conclusions The results suggested that there was some correlation between serum TAC,TGF-β1 content and silicosis in the coal mine workers exposed to silica dust. |
Keywords: silicosis tunneling miner total antioxidant capacity(TAC) transfonning growth factor-pl(TGF-pl) |