摘 要: 肺纤维化 (pulmonary fibrosis, PF) 是多种因素引起的弥漫性肺间质疾病, 以弥漫性肺泡炎和肺泡结构紊乱为特征。氧化应激是 PF 的发病机制之一, 在PF病理过程中发挥着重要作用。Keap1/Nrf2/ARE信号通路是细胞内抗氧化应激的主要途径。近年来研究发现,中药提取物及复方制剂能够通过调控Keap1/Nrf2/ARE 信号通路抑制或延 缓氧化应激反应, 降低纤维化程度, 保护肺组织。本文拟就中药调控Keap1/Nrf2/ARE信号通路对PF进行干预的研究情况作一综述,以期为PF的临床靶向治疗提供参考。 |
关键词: 肺纤维化(PF) 氧化应激 Keap1/Nrf2/ARE信号通路 中草药 |
中图分类号: R135. 2
文献标识码: A
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基金项目: 山东省中医药科技项目(M-2022257) |
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Keap1 / Nrf2 / ARE related signaling pathway of pulmonary fibrosis diseases and its regulation by traditional Chinese medicine |
CHANG Yuqian, SUN Yinling, ZHANG Wei, LI Jing, YANG Zhifeng, ZHANG Haidong, WANG Rui
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Shandong First Medical University / Shandong Provincial Academy of Medical Sciences/ Shandong Provincial Institute of Occupational Health and Occupational Disease Control, Jinan, Shandong 250062, China
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Abstract: Pulmonary fibrosis (PF) is a diffuse interstitial lung disease caused by many factors, characterized by diffuse alveolitis and alveolar structural disorder. Oxidative stress is one of the pathogenesis of pulmonary fibrosis and plays an important role in the pathological process of PF; the Keap1 / Nrf2 / ARE signaling pathway is the main pathway for intracellular oxidative stress. In recent years, studies have found that traditional Chinese herbal extracts and their polypills can inhibit or delay oxidative stress response by regulating the Keap1 / Nrf2 / ARE pathway, reduce the degree of fibrosis, thereby play a role in protecting the lung tissues. This paper will make a review on the research on the intervention of traditional Chinese herbs in the Keap1 / Nrf2 / ARE signaling pathway to PF, in order to provide a reference for the clinical targeted therapy of PF. |
Keywords: pulmonary fibrosis (PF) oxidative stress Keap1 / Nrf2 / ARE singaling pathway Chinese medicinal herbs |